Quantitative changes in focal adhesion kinase and its 1 inhibitor , FRNK , drive load - dependent expression of 2 costamere components 3 4
نویسندگان
چکیده
costamere components 3 4 Stephan Klossner, Ruowei Li, Severin Ruoss, Anne-Cécile Durieux, Martin 5 Flück 6 7 8 Affiliation: Department of Anatomy, University of Berne, Berne, Switzerland 9 Institute for Biomedical Research into Human Movement and Health, Manchester 10 Metropolitan University, Manchester, United Kingdom 11 Department of Cardiovascular Surgery, University Hospital of Berne, Switzerland 12 13 : corresponding author 14 Institute for Biomedical Research into Human Movement and Health 15 School for HealthCare Science 16 Manchester Metropolitan University 17 Oxford Road 18 Manchester M1 5GD 19 United Kingdom 20 Tel: 0044 161 247 5417 21 Fax: 0044 161 247 5457 22 email: [email protected] 23 24 25 26 27 28 29 30 31 Running title: Costameres during load-dependent muscle plasticity 32 33 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (July 31, 2013). doi:10.1152/ajpregu.00007.2013
منابع مشابه
Quantitative changes in focal adhesion kinase and its inhibitor, FRNK, drive load-dependent expression of costamere components.
Costameres are mechanosensory sites of focal adhesion in the sarcolemma that reinforce the muscle-fiber composite and provide an anchor for myofibrillogenesis. We hypothesized that elevated content of the integrin-associated regulator of costamere turnover in culture, focal adhesion kinase (FAK), drives changes in costamere component content in antigravity muscle in a load-dependent way in corr...
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Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK). We hypothesized that changes in content of costamere components (beta 1 integrin, FAK, meta-vinculin, gamma-vinculin) with increased and reduced loading of human anti-gravity muscle would: (i) re...
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Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in adhesion-dependent signal transduction. FAK is highly expressed in cultured neonatal rat ventricular myocytes (NRVMs) and undergoes tyrosine autophosphorylation in response to cell adhesion, stretch, and growth factor stimulation. We previously showed that inhibition of FAK phosphorylation by adenovirally mediated ...
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OBJECTIVE Focal adhesion kinase-related nonkinase (FRNK), the C-terminal domain of focal adhesion kinase (FAK), is a tyrosine-phosphorylated, vascular smooth muscle cell (VSMC)-specific inhibitor of cell migration. FRNK inhibits both FAK and proline-rich tyrosine kinase 2 (PYK2) in cultured VSMCs, and both kinases may be involved in VSMC invasion during vascular remodeling. METHODS AND RESULT...
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